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KMID : 0363420070210020109
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Journal of Korean Oriental Pediatrics
2007 Volume.21 No. 2 p.109 ~ p.119
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The Study of Seunggal-tang Gamibang on the Anti-allergy Effects
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Ju Bong-Hyun
Lyu Sun-Ae
Ko Woo-Shin
Kim Own-Il
Lee Seung-Yeon
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Abstract
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Objectives: The purpose of this study is to investigate effects of Seunggal-tang gamibang (SGT) on the PMA plus A23187-induced RBL-2H3 cells.
Methods:The effect of SGT on ${\beta}$ -hexosamonidase release, passive cutaneous anaphylaxis, $TNF-{\alpha}$ production and IL-4 secretion was studied.
Results:SGT inhibited the release of ${\beta}$ -hexosamonidase in RBL-2H3, without affecting cell viability. The passive cutaneous anaphylaxis (PCA) was inhibited by the SGT. Moreover SGT also reduced production of $TNF-{\alpha}$ and secretion of IL-4 in a dose-dependent manner.
Conclusion:SGT has anti-allergy effects on the RBL-2H3 cells.
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KEYWORD
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Seunggal-tang gamibang, anti-allergy, RBL-2H3 cells
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